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Cure for MS is at hand

That's the headline anyway.

"A Singapore medical research team has made a breakthrough discovery that could finally lead to a cure for multiple sclerosis (MS)."

Read a news summary here.

The MS Society says:
"In our opinion, the press release greatly overstates the discovery's impact. Additional work along the same lines is ongoing, funded by the National MS Society, NIH and other agencies, that will ultimately fit the
pieces of this puzzle together and aid in the development of new therapeutic strategies for MS.

Research Programs Department
National Multiple Sclerosis Society"

Or for those more scientifically inclined here is the abstract:

cell.115.2.gif"Axon-derived molecules are temporally and spatially required as positive or negative signals to coordinate oligodendrocyte differentiation. Increasing evidence suggests that, in addition to the inhibitory Jagged1/Notch1 signaling cascade, other pathways act via Notch to mediate oligodendrocyte differentiation. The GPI-linked neural cell recognition molecule F3/contactin is clustered during development at the paranodal region, a vital site for axoglial interaction. Here, we show that F3/contactin acts as a functional ligand of Notch. This trans-extracellular interaction triggers γ-secretase-dependent nuclear translocation of the Notch intracellular domain. F3/Notch signaling promotes oligodendrocyte precursor cell differentiation and upregulates the myelin-related protein MAG in OLN-93 cells. This can be blocked by dominant negative Notch1, Notch2, and two Deltex1 mutants lacking the RING-H2 finger motif, but not by dominant-negative RBP-J or Hes1 antisense oligonucleotides. Expression of constitutively active Notch1 or Notch2 does not upregulate MAG. Thus, F3/contactin specifically initiates a Notch/Deltex1 signaling pathway that promotes oligodendrocyte maturation and myelination."

Got it? Read the rest here (subscription required).

October 31, 2003 in research | Permalink

Comments

How is the Singapore research coming along? Will we hear of anhing new from the doctors/researchers when I die years later of when the doctor is no longer practicing medicine, retires and enters his twilight years?

Thank you for your reply!

Posted by: Winston at Mar 19, 2004 7:57:13 AM

Please explain that pill derived from
marijuana.

Posted by: joseph paquette at Dec 21, 2003 5:39:04 PM